Faulty cell signaling derails cerebral cortex development, could it lead to autism?
The left pictures reveals typical mind cell group in management mice. The precise pictures reveals deleting the protein APC in progenitor cells derailed regular neuron era and migration. Credit score: Anton Lab, UNC College of Drugs Because the embryonic mind develops, an extremely advanced cascade of mobile occasions happen, beginning with progenitors -- the originating cells that generate neurons and spur correct cortex growth. If this cascade malfunctions -- if one tiny protein does not do its job -- then the mind can develop abnormally. UNC scientists led by Eva Anton, PhD, professor of cell biology and physiology within the UNC College of Drugs, have proven how the deletion of the protein APC in progenitor cells results in huge disruption of mind growth and the canonical Wnt protein pathway -- a signaling cascade- that beforehand was linked to genes related to autism. "Though our experiments have been executed in mouse geneti...